New publication: “A primer on systematic reviews in toxicology”Response to EFSA consultation on weight-of-evidence methodsovercite: the new newsletter from policyfromscience.comSecond international expert workshop: standards for systematic reviews; efficient use of resourcesComments on the latest redraft of the EDC Criteria

IMPORTANT NOTICE / 8 August 2020

This is a legacy site and not maintained as of June 2017. The LRAT Tool is still sometimes used by researchers. LRAT is an early version of an appraisal tool which has since been substantially revised and re-released as CREST, on a new website. While users may still find LRAT to be of value, more recent tools may have advantages in terms of validity, appraisal process, domain coverage etc.


This is the unofficial website for work at Lancaster University, investigating how systematic review methods can help scientists and policy-makers make best use of the best evidence in assessing and managing health risks posed by chemicals.

The site is maintained by Paul Whaley, a research consultant, Associate Editor for Systematic Reviews at Environment International, and part-time PhD student at Lancaster Environment Centre. (More information here.)

Some project highlights

Special Issue: “Systematic Review Methods for Advancing Chemical Risk Assessmentk”. The Special Issue we edited in Environment International.

PublicationImplementing systematic review techniques in chemical risk assessment: Challenges, opportunities, recommendations. (Open access.)

Web tool. PFS Literature Review Appraisal Toolkit. Aiding the critical appraisal of literature reviews.

ReportSystematic Review and the future of evidence in chemicals policy. Outlining how techniques from EBM may be applied to chemical safety assessment.